用孟德尔随机化方法绘制风险基因图，研究单结果和多结果以及年龄变化效应

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:Mendelian randomization (MR) is widely used to infer causal effects of exposures on complex diseases. Increasingly, MR has been applied to molecular traits, such as gene expression, DNA methylation, splicing, and alternative polyadenylation, to identify putative disease genes and regulatory mechanisms. However, transcriptome-wide MR presents several challenges: cis-QTL instruments are often limi…